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Moumoujus

RESVERATRYL TRIACETATE.

Valuable CAS 42206-94-0 / SKIN CONDITIONING, SKIN PROTECTING

Resveratryl Triacetate is an acetylated derivative of resveratrol, designed for enhanced stability and skin penetration. Functioning as a prodrug, it converts into active resveratrol within the skin to deliver potent antioxidant, anti-aging, and skin-brightening benefits. It offers a well-tolerated profile, making it suitable for various skin concerns.

Summary

Skin Brightening Antioxidant Anti-aging Anti-inflammatory Melanin Inhibition

Science

Mechanism of Action

Upon topical application, Resveratryl Triacetate is metabolized by endogenous esterases in the skin, releasing active resveratrol. Resveratrol exerts its effects through multiple pathways: it directly inhibits human tyrosinase activity and suppresses the synthesis of melanogenic enzymes, thereby reducing melanin production. Additionally, it acts as a powerful antioxidant by scavenging Reactive Oxygen Species (ROS) and upregulating cellular antioxidant defenses via Nrf2 mechanisms. Its anti-inflammatory properties and inhibition of Matrix Metalloproteinases (MMPs) further contribute to its comprehensive anti-aging efficacy.

Research

Clinical Evidence

High confidence
Effective range 0.4–0.8%
Optimal

N/A

Key findings

  1. 01 Demonstrated significant skin depigmentation in human subjects over eight weeks with twice-daily application, observed in both artificial tanning (22 subjects) and hyperpigmentation (21 subjects) models.
  2. 02 Exhibited anti-aging effects, leading to improvements in key skin parameters including facial wrinkles, sagging, elasticity, dermal density, moisture levels, and overall brightness.

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding common dusting practices or established dusting thresholds for Resveratryl Triacetate.

The Formula

Formulation

Solubility
Oil
Optimal pH 3 – 7
0 7 14

Stability

Resveratryl Triacetate is an acetylated form engineered for superior stability compared to resveratrol, offering increased resistance to oxidative discoloration. The optimal pH range for the active form (resveratrol) is 3 to 7. Stability decreases significantly above pH 6.8, and exposure to higher pH values or strong oxidizing agents may lead to product discoloration.

Conflicts

  • strong oxidizing agents
  • pH values above 7

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Patch testing at concentrations of 0.1% and 0.5% in human subjects did not induce any skin reactions, indicating a low irritancy potential. This low irritancy profile is notable, as 0.5% resveratrol has been shown to cause mild irritation in similar tests.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Resveratryl Triacetate is a valuable ingredient, effectively targeting hyperpigmentation and multiple signs of aging by delivering a stable, well-tolerated form of resveratrol with proven clinical efficacy.

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