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Moumoujus

RESVERATRYL ACETATE.

Valuable CAS 411233-11-9 / ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Resveratryl Acetate (RTA) is an advanced prodrug form of resveratrol, designed for enhanced stability and effective delivery into the skin. Upon conversion to resveratrol, it offers powerful antioxidant protection, significant skin brightening, and comprehensive anti-aging benefits to promote a radiant and youthful complexion.

Summary

Skin Lightening Antioxidant Anti-aging Anti-inflammatory UV Protection

Science

Mechanism of Action

As a 'prodrug,' Resveratryl Acetate is hypothesized to be enzymatically converted into active resveratrol within skin cells. Resveratrol then exerts its effects by inhibiting the catalytic activity and gene expression of tyrosinase, a crucial enzyme in melanin synthesis, and suppressing the maturation of other melanogenic enzymes. It actively scavenges reactive oxygen species (ROS), enhances the skin's cellular antioxidant capacity through Nrf2-dependent mechanisms, and mitigates inflammatory responses. Additionally, it contributes to protection against UV damage, stimulates keratinocyte differentiation, and delivers broad anti-aging benefits.

Research

Clinical Evidence

High confidence
Effective range 0.4–0.8%
Optimal

0.8%

Key findings

  1. 01 In human studies, 0.4% RTA demonstrated significant skin lightening, increasing ITA° by 17.60% in an artificial tanning model and reducing pigmentation intensity by 2.67% in natural hyperpigmentation, both observed after 8 weeks.
  2. 02 A clinical evaluation using 0.8% RTA showed enhanced skin lightening effects, resulting in a 20.38% increase in ITA° in an artificial UV-induced tanning model after 8 weeks. This concentration also delivered comprehensive anti-aging benefits, improving facial skin wrinkles, sagging, elasticity, dermis denseness, moisture, and overall brightness.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 6
0 7 14

Stability

Resveratryl Acetate demonstrates improved resistance to oxidative discoloration and enhanced stability compared to its parent compound, resveratrol. Resveratrol itself is highly lipophilic, making it soluble in oils and ethanol, but practically insoluble in water. Its stability is significantly influenced by pH and temperature, with degradation accelerating exponentially above pH 6.8. Optimal stability for resveratrol is typically observed between pH 5 and 6, and it is also susceptible to photodegradation upon UV light exposure.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Resveratryl Acetate has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS). However, human primary skin irritation patch tests conducted with 0.1% and 0.5% RTA did not induce any adverse skin reactions, suggesting a low irritancy profile. In the U.S., cosmetic manufacturers are responsible for ensuring ingredient safety, as FDA pre-market approval is not required for cosmetic ingredients other than color additives.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Resveratryl Acetate is a valuable ingredient, clinically proven to deliver significant skin lightening and comprehensive anti-aging benefits with a low irritancy risk, making it suitable for sensitive skin.

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