Science
Mechanism of Action
This ingredient functions as a fusion peptide, produced through E. coli fermentation, combining the genetic sequences for Oligopeptide-133 and sh-Oligopeptide-2. The sh-Oligopeptide-2 component mimics Insulin-like Growth Factor-1 (IGF-1), binding to specific receptors on skin cells to activate a cascade of events, including the AKT pathway, which supports collagen production and enhances skin elasticity. This process also promotes new blood vessel formation, revitalizes aged cells, and improves the biosynthesis of hyaluronic acid and other crucial extracellular matrix components. Concurrently, Oligopeptide-2 within the fusion peptide accelerates the synthesis of collagen types I, III, and IV, fibronectin, and polysaccharides, while boosting the expression of wound repair genes to promote tissue regeneration and reduce the appearance of fine lines and deep wrinkles.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The European Cosmetics Directive has recognized SH-Oligopeptide-2 as safe for cosmetic use, but advises caution and recommends a sensitivity test due to potential allergy cases. As a growth factor-mimicking peptide, there is a theoretical correlation with tumorigenesis or disease progression; recombinant IGF-1, specifically, has been linked to melanoma progression, warranting careful consideration for product development.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its promising mechanism for stimulating collagen and promoting skin regeneration, the ingredient's lack of comprehensive safety review by CIR and potential theoretical correlation with tumorigenesis render its inclusion questionable without further robust clinical and safety data.
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References
Sources