Science
Mechanism of Action
This oligopeptide functions by specifically binding to receptors on the surface of epidermal cells. This interaction activates signaling pathways that stimulate cell growth, proliferation, and differentiation, contributing to skin regeneration, accelerated wound healing, and maintaining skin thickness. It also supports the epidermal growth factor signaling pathway to enhance the production of healthier skin cells and improve overall skin hydration.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Clinical assessments on 'Oligopeptide-1' have reported statistically significant improvements in the appearance of fine lines, skin texture, pore size, and various dyschromatic conditions within the initial month of use, additionally noting benefits in nourishing, smoothing, lightening, rejuvenating tired skin, and assisting in scar removal.
- 02 Conversely, a study evaluating sh-oligopeptide-1 (often used interchangeably) at 10 µg/g for reducing post-laser edema and hyperpigmentation found it 'behaved identically to the control,' raising questions about its functional efficacy as an EGF.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Oligopeptide-1 is highly sensitive to pH, requiring the final product pH to be within 5.0-7.0 (or 5-8 for creams before adding a diluted solution) for optimal stability. It is susceptible to decomposition by microbial enzymes, making rigorous avoidance of microbial contamination crucial during manufacturing and post-opening. This ingredient should be incorporated in the final production stage, with temperatures not exceeding 40℃. Optimal storage conditions are between 2-8℃, protected from light, in a sealed container, with an approximate expiry of 18 months.
Safety
Safety Profile
R-Bovine Oligopeptide-1 is not listed on EWG's Restricted or Unacceptable Lists and is considered unlikely to be carcinogenic. It was recognized in IECIC 2015 as a common skin-conditioning agent. However, a critical review concluded that many clinical studies on sh-oligopeptide-1 lack scientific rigor and preclinical bioactivity is unproven. The same review cautioned that while generally authorized in cosmetics, its long-term risks remain unknown, noting that active EGF is considered a potent, unauthorized drug.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While R-Bovine Oligopeptide-1 is attributed with significant anti-aging and regenerative potential, its clinical efficacy is met with contradictory scientific findings, and its long-term safety profile in cosmetic applications remains unestablished.
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