Science
Mechanism of Action
Quassin's mechanism involves immunomodulatory effects, influencing inflammatory pathways. It has been observed to enhance nitric oxide (NO) generation and inducible nitric oxide synthase (iNOS2) expression, and in specific contexts, up-regulate pro-inflammatory cytokines such as TNF-α and IL-12. As a natural triterpenoid, Quassin belongs to a class of compounds known to reduce skin inflammation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A topical gel containing 4% Quassia amara extract effectively reduced symptoms of facial seborrheic dermatitis and rosacea, demonstrating good efficacy and excellent safety and tolerability over time. This suggests potential for Quassin's benefits.
Transparency
Dusting Analysis
No specific data on dusting or common overuse thresholds for Quassin in cosmetic formulations were identified in the research data.
The Formula
Formulation
Stability
Quassin is stable under typical storage conditions, but it is susceptible to degradation when exposed to light and heat. Its pH in solution is generally neutral.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has determined that there is insufficient data to support the safety of Quassin or alcohol denatured with Quassin for cosmetic use, requiring further information to reach a conclusion. However, Quassia is listed as Generally Recognized As Safe (GRAS) by the FDA for food use. A study involving topical application of Quassia extract for head lice reported no adverse reactions, suggesting a potential for good tolerability in some contexts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While showing promising efficacy in reducing symptoms of inflammatory skin conditions when used as 4% Quassia amara extract, Quassin's overall safety for cosmetic use requires further data according to the CIR Expert Panel.
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References
Sources