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Moumoujus

QUASSIA AMARA WOOD EXTRACT.

Valuable CAS 84604-10-4 / DENATURANT, SKIN CONDITIONING, TONIC

Quassia Amara Wood Extract is a multi-functional botanical ingredient, rich in quassinoids and other beneficial compounds. It offers a precise approach to addressing diverse skin concerns, from microbial imbalances and inflammation to promoting collagen synthesis and enhancing skin resilience. This extract is highly valued for its comprehensive benefits across various skin types.

Summary

Skin-conditioning Antioxidant Anti-acne Anti-inflammatory Antimicrobial Sebum-regulating Astringent Soothing Collagen-boosting Moisturizing Anti-aging

Science

Mechanism of Action

This extract operates through multiple synergistic pathways. It demonstrates robust antibacterial and anti-inflammatory activity, effectively reducing acne-causing bacteria like P. acnes (by 58%) and mitigating inflammation, which is crucial for conditions such as seborrheic dermatitis and rosacea by decreasing Demodex mites. As an antioxidant, it neutralizes free radicals, thereby protecting against premature aging and stimulating Type I collagen production. Furthermore, it regulates sebum, acts as an astringent, and enhances skin's appearance by moisturizing and restoring suppleness. Preliminary research also suggests a potential 'botox-like effect' through acetylcholine metabolism inhibition and support for extracellular matrix stabilization via Lysyl Oxidase (LOX) expression.

Research

Clinical Evidence

High confidence
Effective range 4%–10%%
Optimal

4%

Key findings

  1. 01 A 4% topical gel significantly reduced facial seborrheic dermatitis, demonstrating a notable advantage over comparator treatments (2% ketoconazole, 1% cyclopiroxolamine).
  2. 02 Topical treatment with 4% extract dramatically decreased Demodex spp. mites in patients presenting with erythematotelangiectatic and papulopustular subtypes of rosacea.
  3. 03 Applied topically at 4% over 42 days, the extract achieved a 58% reduction in P. acnes and a 50.8% reduction in coagulase-positive Staphylococcus on the skin.
  4. 04 In vitro, the extract displayed potent antifungal properties against various Candida species (C. albicans, C. parapsilosis, C. glabrata, C. krusei) and Malassezia furfur at concentrations ranging from 5% to 10% (corresponding to 0.0382% to 0.0764% w/w quassin).

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding dusting practices or typical dusting thresholds for Quassia Amara Wood Extract in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Quassia (from Picrasma excelsa or Quassia amara) is listed by the FDA as 'may be safely used in food' and is approved by the Council of Europe for use. It is also recognized in several European Pharmacopoeias. Oral toxicity studies in rats (up to 1000 mg/kg) and mice (up to 5000 mg/kg) showed no toxic effects or mortality. While intraperitoneal injection at high doses (500-1000 mg/kg) caused acute toxicity in mice, a No Observed Adverse Effect Level (NOAEL) of 35 mg/kg and a Reference Dose (RfD) of 0.35 mg/kg/day have been identified from oral studies. The Scientific Committee on Food has re-evaluated quassin, indicating ongoing safety assessment.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Quassia Amara Wood Extract is a highly valuable multi-active ingredient, providing scientifically supported benefits for common skin concerns like acne, rosacea, and seborrheic dermatitis, alongside anti-aging and conditioning properties with low irritancy.

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