Science
Mechanism of Action
This ingredient functions by specifically targeting the dermal papilla within hair follicles. It enhances nutrient and oxygen supply to the hair root through capillary dilation, a process critical for rejuvenating weakened hair follicle cells. Its action extends the anagen (growth) phase of the hair cycle and stimulates new hair regeneration by promoting hair papilla cell proliferation. Additionally, it facilitates the opening of potassium ion channels and boosts hair matrix cell division, which collectively contribute to increased hair strength, volume, and improved root anchorage. Beyond its primary role in hair, it also supports skin health by improving local microcirculation, providing moisturization, and addressing scalp concerns like dandruff and itching. Preliminary data also suggests potential benefits for reducing the appearance of wrinkles and diminishing dark circles or age spots.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 In an open-label, phase II study on 60 male subjects using 0.1-1.5% Kopyrrol Aqua, an mRNA value for the SHH gene (associated with hair growth) increased by 13.50%, which was notably higher than Minoxidil's 5%. This resulted in a significant improvement in hair growth percentages: 25% by month 2, 50% by month 4, and 66% by month 5. The formulation was well-tolerated with no adverse events.
- 02 A topical nanosomal solution containing Pyrrolidinyl Diaminopyrimidine Oxide was applied to women with early-stage Female Pattern Hair Loss (FPHL). Subjects experienced a significant decrease in hair shedding, with the mean score reducing from 3.5 at baseline to 2.0 by month 3 and 1.6 by month 6. Hair Mass Index (HMI) notably increased from 75.8 mm²/cm² to 84.3 mm²/cm² after 3 months, with 75% reporting visible improvements in overall hair density. The formulation demonstrated good tolerability.
- 03 A study involving 60 men demonstrated that Pyrrolidinyl Diaminopyrimidine Oxide Oxothiazolidinecarboxylate enhanced the expression of hair growth-related mRNA by up to 13.5%, achieving twice the effect observed with Minoxidil.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient maintains optimal stability within a pH range of 3.5 to 6.5. It is readily soluble in water, allowing for formulations with up to 95% water content. To preserve its integrity, processing temperatures should not exceed 80°C.
Safety
Safety Profile
The primary active component, Pyrrolidinyl Diaminopyrimidine Oxide, is generally considered safer than Minoxidil, with no adverse events reported in the provided clinical studies. It has received approval for use in personal care products in Europe, the United States, and Japan. While a related compound, 2,4-DPO, was deemed safe for cosmetic use at 1.5% by the SCCS, surveillance was recommended as a new substance. This compound is classified as 'Harmful if swallowed' (H302) under GHS, requiring appropriate handling. Topical concentrations are typically recommended between 0.1% and 5% to balance efficacy and formulation stability.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient is a valuable active for hair growth and scalp health formulations, demonstrating superior efficacy to Minoxidil in some metrics and a favorable safety profile.
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