Science
Mechanism of Action
This compound, also identified as quinolinic acid, operates by negatively regulating the aryl hydrocarbon receptor (AhR)-NLRP3 inflammasome signaling cascade. This specific modulatory action is implicated in reducing inflammatory responses within the skin, notably observed in psoriasis models.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The ingredient is stable under normal conditions of temperature and pressure. It is susceptible to degradation by moisture. The pKa for 2,3-Pyridinedicarboxylic acid is 3.1.
Conflicts
- strong oxidizing agents
- moisture
Safety
Safety Profile
No specific Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) assessment has been conducted for Pyridinedicarboxylic Acid in cosmetic applications. Safety Data Sheets for the raw form indicate it can cause skin and serious eye irritation. There is no specific FDA status for its use in cosmetics.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising anti-inflammatory findings in preclinical models, the high irritancy potential and lack of established cosmetic safety data make this ingredient questionable for skincare applications.
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References
Sources