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Moumoujus

PYRICARBATE.

Insufficient Data CAS 1882-26-4 / CHELATING, SKIN CONDITIONING

Pyricarbate is a versatile ingredient recognized for its dual anti-inflammatory and antioxidant capabilities. It functions by inhibiting pro-inflammatory cytokines and neutralizing reactive oxygen species, thereby protecting skin from oxidative damage and inflammatory responses. This makes it potentially beneficial for concerns such as eczema, dermatitis, and the visible signs of skin aging.

Summary

Anti-inflammatory Antioxidant Chelating Agent

Science

Mechanism of Action

Pyricarbate exerts a dual action within the skin, functioning as both an anti-inflammatory and an antioxidant agent. It actively mitigates inflammatory responses by inhibiting the production of pro-inflammatory cytokines. Concurrently, it neutralizes harmful reactive oxygen species (ROS), safeguarding dermal cells from oxidative stress and associated damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Pyricarbate maintains optimal stability within the typical skincare pH range of 4.5 to 6.5, which also supports skin barrier function. For bulk storage, it should be kept dry, dark, and refrigerated at 0-4°C for short periods or frozen at -20°C for extended stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Pyricarbate is listed with FDA UNII (81R511UV73) and is categorized as a chelating agent in cosmetic databases. The Cosmetic Ingredient Review (CIR) has not yet assessed its safety. While oral LD50 values indicate moderate toxicity upon ingestion (e.g., 1000 mg/kg in dogs, 4500 mg/kg in mice), these figures are not directly applicable to topical dermal exposure. Currently, no specific maximum concentration for its topical use in cosmetics has been established.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Pyricarbate demonstrates promising anti-inflammatory and antioxidant properties, comprehensive topical clinical efficacy data and a safety assessment by the CIR for cosmetic use are currently lacking, necessitating further research before widespread recommendation.

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