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PSEUDANABAENA GALEATA EXTRACT.

Avoid / SKIN CONDITIONING

Pseudanabaena Galeata Extract, derived from a cyanobacterium, is generally categorized as a skin conditioning agent. However, research indicates significant cytotoxic effects on human dermal fibroblasts at low concentrations, raising considerable safety concerns for topical application.

Summary

Skin Conditioning

Science

Mechanism of Action

The observed cytotoxic activity of Pseudanabaena galeata is linked to specific lipid classes, primarily diacylglycerols (DAGs) and monogalactosyldiacylglycerols (MGDGs). While broadly classified as a skin conditioning agent, its cellular mechanism in beneficial skin applications is not elucidated by the provided data.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A cellular extract of Pseudanabaena galeata CCNP1313 at 200 µg/mL reduced the viability of human dermal fibroblasts (HDFa) by 92% after 24 hours.
  2. 02 The most potent cytotoxicity against human dermal fibroblasts (HDFa) was observed for a specific fraction (F20%.1) with an IC50 of 66 ± 5 µg/mL.
  3. 03 Fractions of Pseudanabaena galeata CCNP1313 demonstrated cytotoxicity against various cancer cell lines (HeLa, CaSki, C-33A) with IC50 values ranging from 83 ± 7 to 95 ± 13 µg/mL.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
66 ± 5 µg/mL (0.0066% ± 0.0005% w/v)%
Red flag below
0.0066% w/v%

Pseudanabaena galeata Extract is commonly listed as a skin conditioning agent and used in skincare products. However, clinical data unequivocally demonstrates severe cytotoxicity to human dermal fibroblasts at concentrations as low as 0.0066% w/v, representing a significant discrepancy between its perceived role and actual biological effects on skin cells.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 8
0 7 14

Stability

Components of the extract, such as C-phycoerythrin found in marine Pseudanabaena species, show stability within a pH range of 3-8 and temperatures of 4-40°C, with optimal stability at pH 7.0 for up to 6 hours under light exposure. The extract contains both water-soluble (e.g., phycobiliproteins, some toxins) and hydrophobic (e.g., cytotoxic lipid classes) components.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

No specific safety status has been established by CIR, SCCS, or FDA. Certain Pseudanabaena strains are known to produce potent toxins, including microcystins, anatoxin-a, and saxitoxin. Oral administration of Pseudanabaena galeata extract at 1,000 mg/kg bw in mice resulted in severe intoxication, causing transient symptoms and lesions in the liver and kidneys. Crucially, a cellular extract (200 µg/mL) demonstrated high cytotoxicity against human dermal fibroblasts, reducing their viability by 92%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite being classified as a skin conditioning agent and found in cosmetic formulations, Pseudanabaena Galeata Extract exhibits significant cytotoxicity towards human dermal fibroblasts at low concentrations and has demonstrated severe systemic toxicity in animal studies, indicating its topical application is highly questionable and potentially harmful.

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