Science
Mechanism of Action
This extract operates through multiple pathways to enhance skin vitality. It demonstrates anti-inflammatory effects by modulating the NF-κB and AP-1 signaling pathways, effectively reducing cellular reactive oxygen species (ROS) levels. Rich in flavonoids like loliolide and alverine, it acts as a powerful antioxidant, concurrently exerting antiapoptotic and anti-melanogenic properties on various skin cell lines.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro, a chloroform fraction (Pj-EE-CF) at 50 and 100 μg/mL significantly reduced NF-κB signaling, suppressed nitric oxide levels, and decreased inflammatory cytokine gene expression in LPS-stimulated macrophages.
- 02 Oral administration of Pj-EE-CF at 25, 50, and 100 mg/kg in mice alleviated histopathological changes and reduced paw edema in carrageenan-treated paws.
- 03 An ethanol extract demonstrated no cytotoxicity to B16F10 cells at concentrations up to 200 µg/mL.
- 04 General findings suggest the ethanol extract exerts antiapoptotic, anti-melanogenic, and antioxidant effects on various skin cell lines.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Specific safety assessments by major regulatory bodies such as CIR, SCCS, or FDA for Prasiola Japonica Extract are currently unavailable. Prasiola japonica is a green algae, distinct from red or brown algae which may have broader reviews. INCIDecoder also indicates an 'unknown' safety rating, with no data on irritancy or comedogenicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While preliminary in-vitro and animal studies suggest promising anti-inflammatory, antioxidant, and skin-benefiting properties, the absence of human topical clinical data and formal safety assessments by regulatory bodies results in an 'insufficient data' rating for definitive guidance.
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