Science
Mechanism of Action
PGA inhibits hyaluronidase, enhancing hyaluronic acid's longevity and functionality in the skin. It stimulates natural moisturizing factors and collagen, forming a protective barrier to reduce water loss while providing antioxidant and tyrosinase-inhibiting properties.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 An 8-week clinical study showed a 172% increase in skin hydration after 1 hour and a 122% improvement in elasticity.
- 02 Formulations demonstrated 45% enhanced water retention and 13.5% superior skin hydration compared to glycerol.
- 03 At 0.008%, it achieved 97% hyaluronidase inhibition; at 0.004%, it protected 92% of hyaluronic acid.
Transparency
Dusting Analysis
No data indicates that Potassium Hydrolyzed Polygamma-Glutamate is commonly dusted. Its efficacy is observed at very low concentrations.
The Formula
Formulation
Stability
Polyglutamate salts are generally stable within a pH range of 5.0 to 7.5. Hydrolysis can be affected by lower pH and higher temperatures.
Synergies
- Hyaluronic Acid
Conflicts
- Carboxy vinyl polymer (can cause viscosity decline in equal concentrations)
Safety
Safety Profile
While not CIR reviewed, its base polymer PGA is recognized as safe, biodegradable, non-toxic, and non-immunogenic. It's well-tolerated, though concentrations above 3% are not recommended to avoid potential redness. SkinSafe categorizes it as 'Irritant Free'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Potassium Hydrolyzed Polygamma-Glutamate is a highly effective, multi-functional ingredient known for superior hydration, anti-aging benefits, and excellent skin compatibility across all skin types.
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