Science
Mechanism of Action
The primary function of Ponceau SX in formulations is as a colorant, providing a distinct red pigmentation. In biological systems, this compound has been observed to act as a histamine liberator, which may precipitate allergic reactions or other adverse effects in individuals with sensitivities.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ponceau SX demonstrates excellent solubility in water and exhibits good stability under acidic conditions. It also possesses substantial thermal stability, with a melting point recorded above 300 degrees Celsius.
Conflicts
- Acids
- Aldehydes
- Amides
- Carbamates
- Cyanides
- Inorganic fluorides
- Halogenated organics
- Isocyanates
- Ketones
- Metals
- Nitrides
- Peroxides
- Phenols
- Epoxides
- Acyl halides
- Strong oxidizing agents
- Strong reducing agents
- Alkali metals
- Metal salts
- Sulfides
Safety
Safety Profile
Ponceau SX (FD&C Red No. 4, CI 14700) is permanently listed in the United States, requiring certification for external cosmetic and drug applications, with a maximum concentration of 6% in skin products. Conversely, it is prohibited in cosmetic products within the European Union, with the exception of hair dye use. The Environmental Working Group (EWG) rates it as 'Unacceptable' due to high use restrictions, potential for endocrine disruption (low), and significant contamination concerns, including lead, arsenic, and mercury. It is noted to cause irritation upon contact with skin and eyes. As a coal tar derivative, Ponceau SX is generally considered comedogenic.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its prohibition in EU cosmetic products, potential to act as a histamine liberator and cause irritation, classification as comedogenic, and high contamination concerns, Ponceau SX is not recommended for precision skincare formulations.
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References
Sources