Science
Mechanism of Action
As a primary film former, POLYURETHANE-21 deposits a continuous polymeric film onto the skin, hair, or nails. This physical barrier provides structural integrity and modifies the surface characteristics of the application area.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In a human dermal irritation study (n=10), Polyurethane-21 applied twice to scarified skin over 24 hours demonstrated a low average irritation score of 0.50 out of 4, indicating minimal potential for dermal irritation.
- 02 A Human Repeat Insult Patch Test (HRIPT) conducted with Polyurethane-21 at 21% solids concentration observed no adverse reactions, confirming its non-sensitizing profile.
Transparency
Dusting Analysis
No data available suggests that POLYURETHANE-21 is commonly associated with dusting during formulation or application.
The Formula
Formulation
Stability
Polyurethanes generally exhibit good stability when stored and handled according to prescribed conditions, though extreme temperatures should be avoided. Formulators should be mindful that some commercial preparations of polyurethanes may include known sensitizers like methylisothiazolinone (MI); vigilance is required to prevent their significant accumulation.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Polyurethane-21, along with 65 other polyurethane ingredients, is safe for cosmetic use under current practices. This safety assessment is based on the assurance of no detectable residual isocyanate or other monomers, and the expectation that the ingredient will be formulated to be non-sensitizing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
POLYURETHANE-21 is a valuable, safe, and effective film-forming polymer, suitable for a wide range of cosmetic applications and skin types due to its low irritation and sensitization potential.
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References
Sources