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POLYSORBATE 65.

Valuable CAS 9005-71-4 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Polysorbate 65 is a non-ionic surfactant primarily utilized as an emulsifier and solubilizer in cosmetic formulations. It enables the stable blending of immiscible liquids like oil and water by reducing surface tension, which is crucial for uniform product consistency. Additionally, its surfactant properties aid in effective skin cleansing.

Summary

Emulsifying Surfactant/Cleansing Solubilizer Dispersing Agent

Science

Mechanism of Action

As a non-ionic surfactant, Polysorbate 65 functions by lowering the surface tension between different phases, allowing oil and water to mix stably within a formulation. This emulsifying action is key for maintaining product homogeneity and ensuring consistent delivery of active ingredients. In cleansing products, its surfactant nature helps lift and disperse dirt and oils from the skin surface, facilitating their efficient removal.

Research

Clinical Evidence

High confidence
Effective range ≤0.06%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Polysorbate 65 maintains stability with electrolytes, weak acids, and weak bases, but will gradually saponify when exposed to strong acids or bases. Its oleate component is susceptible to oxidation, and prolonged storage, similar to other polyoxyethylene surfactants, may result in peroxide formation. As a hygroscopic substance, it requires storage in a sealed container, protected from light, in a cool and dry environment.

Conflicts

  • Phenol
  • Tannin
  • Tar and tar-like substances (risk of discoloration and/or precipitation)
  • Paraben preservatives (potential to reduce antimicrobial activity)

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Polysorbate 65 is safe for cosmetic use when formulated to be non-irritating. The FDA permits its use as a direct and indirect food additive, and the WHO has established an Acceptable Daily Intake (ADI) of up to 25 mg per kilogram of body weight for total polysorbates. While generally considered non-toxic and non-irritating, rare cases of hypersensitivity have been reported with topical and intramuscular exposure.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Polysorbate 65 is a valuable non-ionic surfactant and emulsifier, widely recognized for its high safety profile and ability to stabilize diverse cosmetic and pharmaceutical formulations without significant irritation or sensitization concerns.

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