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POLYQUATERNIUM-53.

Valuable CAS 84647-38-1 / HAIR CONDITIONING

Polyquaternium-53 is a cationic polymer engineered to adhere to the negatively charged keratin proteins on both hair and skin. It forms a non-occlusive, flexible film that enhances conditioning and manageability, while also helping to reduce moisture loss.

Conditioning Agent Film-forming Antistatic Moisture Barrier

Science

This cationic polymer functions by forming a strong electrostatic bond with the negatively charged keratin on the skin's surface. It creates a thin, highly resistant, and flexible film, serving as a conditioning agent and establishing a protective barrier to minimize trans-epidermal water loss.


Research

Medium confidence
Effective range 0.5–3%
Optimal

N/A

Key findings

  1. 01 Observed to provide conditioning and aesthetic improvements in rinse-off conditioners and serums within a 0.5% to 3% concentration range.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Conflicts

  • High concentrations of anionic surfactants (e.g., Sodium Lauryl Sulfate) may lead to precipitation or loss of functional efficacy.

Safety

CIR Status
Safe with restrictions
Sensitization risk Low

The CIR Expert Panel deems Polyquaternium-53 safe for use in current practices and concentrations, provided it is formulated to be non-irritating. Its use is also subject to restrictions under Annex III of the EC Cosmetics Regulation, potentially related to purity, maximum concentration, or specific product categories.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Polyquaternium-53 is a valuable film-forming and conditioning agent, effective in creating a protective barrier and enhancing skin and hair texture while exhibiting low irritancy.


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