Science
Mechanism of Action
As a cationic polymer, POLYQUATERNIUM-43 electrostatically binds to the negatively charged surface of the skin. This interaction forms a conditioning film that minimizes transepidermal water loss, attracts atmospheric humidity to the skin, and protects against environmental stressors, leading to improved skin hydration and a smoother, softer feel. It can also serve to moderate the penetration or rinse-off of other active ingredients.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Anionic surfactants (can lead to undesirable film or build-up in certain formulations)
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR) has not issued a specific safety assessment for Polyquaternium-43, general polyquaternium ingredients have been reviewed. In Europe, Polyquaternium-43 is included in Annex III (entry 66) of the EC Cosmetics Regulation, signifying that its use is expressly approved but subject to specific restrictions regarding purity, maximum concentration, or product categories, following evaluation by the Scientific Committee on Consumer Safety (SCCS). EWG Skin Deep also indicates 'HIGH' use restrictions based on these EU regulations. No direct FDA cosmetic ingredient status was identified in the available data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
POLYQUATERNIUM-43 is a valuable film-forming and conditioning agent, particularly beneficial for dry skin due to its moisturizing and barrier-enhancing properties, provided its formulation adheres to European cosmetic regulatory restrictions.
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References
Sources