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Moumoujus

POLYPODIUM DECUMANUM EXTRACT.

Insufficient Data CAS - / SKIN PROTECTING

Polypodium Decumanum Extract is derived from a fern historically used to address inflammatory skin conditions, notably psoriasis. This botanical ingredient functions by modulating key inflammatory pathways, offering potential for soothing and calming reactive skin states.

Summary

Anti-inflammatory Soothing Immunomodulating

Science

Mechanism of Action

This extract exerts its action by inhibiting specific inflammatory mediators. In human neutrophils, it demonstrates inhibitory activity against platelet-activating factor, a substance involved in UVB-induced immunosuppression. Furthermore, in an in vitro model utilizing human leukocytes, it effectively reduces the formation of leukotriene B4, an inflammatory compound found in elevated quantities in psoriatic skin. Its complex biochemical composition includes beneficial polyunsaturated fatty acids (such as linoleic, linolenic, and arachidonic acids), along with terpenoids, saponins, and flavonoids, all contributing to its anti-inflammatory profile.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate inhibition of platelet-activating factor in human neutrophils, a mediator of UVB-induced immunosuppression.
  2. 02 In an in vitro model using human leukocytes, the extract inhibited the formation of leukotriene B4, an inflammatory mediator implicated in psoriatic skin.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding the 'dusting' phenomenon or a 'red flag' percentage for POLYPODIUM DECUMANUM EXTRACT is not available in the provided data.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 7.5
0 7 14

Stability

Specific stability data for POLYPODIUM DECUMANUM EXTRACT is not documented. However, the related Polypodium leucotomos extract exhibits stability for 60 months when stored at 25 ± 2 °C and 60 ± 5% relative humidity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Specific safety assessments by CIR or SCCS for POLYPODIUM DECUMANUM EXTRACT are not available. The related Polypodium leucotomos extract is generally considered a low irritant. Oral forms of Polypodium leucotomos extract have shown a favorable safety profile in clinical studies, with minimal side effects (e.g., mild gastrointestinal complaints or pruritus) observed in approximately 2% of patients at daily doses between 120mg and 1080mg. Topical safety and efficacy data for Polypodium decumanum extract itself remains limited.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite promising in vitro anti-inflammatory mechanisms and traditional applications, comprehensive topical clinical data confirming the efficacy and safety of Polypodium Decumanum Extract at specific concentrations for modern skincare remains limited, requiring further research for precision application.

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