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POLYDIMETHYLAMINOETHYL METHACRYLATE.

Insufficient Data CAS - / FILM FORMING

POLYDIMETHYLAMINOETHYL METHACRYLATE (PDMAEMA) is a synthetic polymer characterized by its pH-responsive behavior and demonstrated antibacterial properties. Its physical characteristics, including solubility, are highly sensitive to environmental pH and ionic strength, making it a dynamic component.

Summary

Antibacterial Agent pH-Responsive Polymer Film-Former

Science

Mechanism of Action

PDMAEMA exerts its antibacterial action by initially adsorbing onto the bacterial cell surface. Subsequently, it diffuses through the cell wall and binds to the cytoplasmic membrane, ultimately causing disruption of this vital barrier. As a pH-responsive polymer, its chain conformation, configuration, and solubility can be precisely modulated through strategic manipulation of the solution's pH or ionic strength.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

POLYDIMETHYLAMINOETHYL METHACRYLATE functions as a weak polyelectrolyte with a pKa measured close to 7.9 in an aqueous environment. Its solubility is critically pH-dependent, presenting as water-soluble at pH 4 but exhibiting increased hydrophobicity at pH 10. Furthermore, its thermoresponsive properties are responsive to minor shifts in pH and salinity. Notably, polyplexes formed with this polymer have demonstrated good stability at pH 7.4.

Conflicts

  • Significant changes in pH
  • Significant changes in ionic strength

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

There is no specific safety assessment available from the Cosmetic Ingredient Review (CIR) Expert Panel, Scientific Committee on Consumer Safety (SCCS), or FDA directly for POLYDIMETHYLAMINOETHYL METHACRYLATE as a standalone cosmetic ingredient. While Polymethyl Methacrylate (PMMA) and related crosspolymers have been deemed safe for cosmetic applications, these are distinct ingredients. General safety assessments for 'methacrylate ester monomers' recommend avoiding skin contact due to a potential for sensitization.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Given the absence of a dedicated cosmetic safety review for POLYDIMETHYLAMINOETHYL METHACRYLATE and the stated sensitizing potential of related methacrylate ester monomers, current data is insufficient for a confident recommendation in precision skincare.

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