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POLOXAMINE 904.

Valuable CAS 11111-34-5 / SURFACTANT - EMULSIFYING

Poloxamine 904 is a versatile amphiphilic block copolymer, functioning primarily as a surfactant and emulsifier in skincare formulations. It skillfully reduces interfacial tension, enabling the creation of stable emulsions that seamlessly blend both water-soluble and oil-soluble active ingredients.

Summary

Emulsifying Surfactant

Science

Mechanism of Action

As an amphiphilic block copolymer, Poloxamine 904 operates by lowering the interfacial tension between immiscible phases, such as oil and water. This allows for the uniform dispersion of ingredients, forming stable emulsions. Additionally, its structure permits the formation of polymeric micelles, which can encapsulate and deliver active compounds.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data is available regarding dusting or potential dusting thresholds for Poloxamine 904.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poloxamine 904 exhibits medium hydrophilic properties with an HLB value between 12-18, indicating solubility in both aqueous and oil phases. Its micellization behavior is pH-dependent due to protonable central nitrogen atoms, suggesting potential pH-responsive characteristics in formulations. While specific pH range for optimal stability of Poloxamine 904 is not defined, a related poloxamine (Poloxamine 1304) demonstrates stability across a broad pH range. Poloxamine complexes can be unstable in chlorinated organic solvents when exposed to oxygen, air, or water.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has deemed poloxamers, the broader class to which poloxamines belong, safe for use in cosmetics. The panel emphasized that manufacturers must ensure purification procedures keep impurities like ethylene oxide, propylene oxide, and 1,4-dioxane below established limits. Due to its molecular weight and solubility, minimal and slow skin penetration is expected. Clinical tests for dermal irritation and sensitization on poloxamers have consistently shown negative results. No specific maximum concentration has been set by SCCS for Poloxamine 904, though it is recognized as an emulsifier.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamine 904 is a valuable formulation ingredient, crucial for creating stable and efficacious skincare products by facilitating robust emulsions and supporting diverse active ingredient delivery.

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