Science
Mechanism of Action
This ingredient functions through its amphiphilic structure, comprising poly(ethylene oxide) and poly(propylene oxide) blocks linked by a central tetrakis(propanol) unit containing two tertiary amine groups. This duality enables it to reduce surface tension and form stable emulsions by encapsulating oil droplets within a water phase, or vice-versa. At concentrations exceeding its critical micellar concentration (CMC), Poloxamine 702 can self-assemble into polymeric micelles with a hydrophobic core, facilitating the solubilization and stabilization of poorly water-soluble substances. Beyond its primary role in formulation stability, its surfactant properties are noted to contribute to cleansing, protein aggregation suppression, and the stabilization of antimicrobials in specific applications.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamine 702 exhibits sensitivity to both temperature and pH fluctuations, primarily due to the tertiary amine groups present within its core molecular structure.
Safety
Safety Profile
While acknowledged as an emulsifier in an opinion from the Scientific Committee on Cosmetics and Non-Food Products (SCCNFP), specific detailed safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS), including maximum concentration limits for cosmetic use, are not available in the provided data. There is no explicit FDA cosmetic status for Poloxamine 702, though poloxamines are broadly recognized as drug carriers.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamine 702 is a versatile surfactant and emulsifier valuable for stabilizing complex formulations, yet specific cosmetic efficacy and safety data, including concentration limits and skin compatibility, remain largely uncharacterized in the provided research.
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References
Sources