Science
Mechanism of Action
This ingredient functions by significantly reducing the interfacial tension between immiscible liquid phases, which facilitates the creation and stabilization of emulsions. As a surface-active agent, Poloxamine 701 can interact with mammalian cell membranes, potentially leading to reduced protein adsorption and cell adhesion. While its primary role is formulatory, some poloxamers have been observed in other contexts to aid in wound cleansing and influence matrix metalloproteinase activity.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamines, including Poloxamine 701, demonstrate excellent tolerance to diverse salt concentrations and pH environments, attributed to their nonionic polymeric structure which contributes to robust formulation stability.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that poloxamers, a group inclusive of Poloxamine 701, are safe for use in cosmetic products. This determination is contingent on manufacturing processes ensuring that impurities such as ethylene oxide, propylene oxide, and 1,4-dioxane remain below established limits. Clinical assessments for dermal irritation and sensitization showed consistently negative outcomes for poloxamers. Given its molecular weight and solubility characteristics, Poloxamine 701 is anticipated to exhibit minimal and slow penetration into the skin. Although listed as an emulsifier by the SCCNFP in 1999, no specific recent SCCS opinion detailing restrictions or maximum concentrations has been identified.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamine 701 is a valuable nonionic emulsifier and surfactant, crucial for creating stable product formulations, offering low irritation potential, and suitability for sensitive skin.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources