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POLOXAMINE 504.

Valuable CAS 11111-34-5 / SURFACTANT - EMULSIFYING

Poloxamine 504 is a synthetic polymer primarily employed in skincare formulations as a surfactant and emulsifying agent. Its unique molecular structure allows it to significantly reduce the surface tension of liquids, facilitating the stable blending of oil and water phases to create smooth, consistent products. This function also enables effective cleansing by lifting impurities from the skin.

Summary

surfactant emulsifying

Science

Mechanism of Action

Functioning as a non-ionic surfactant, Poloxamine 504 works by lowering the interfacial tension between immiscible components, such as oil and water. This action creates and stabilizes emulsions, ensuring uniform product texture. On the skin, it aids in solubilizing and removing lipids and dirt particles, making it effective for deep cleansing applications. Due to its molecular characteristics, it exhibits minimal skin penetration.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poloxamines, including Poloxamine 504, are stable in their solid form under standard storage conditions, including normal temperatures and light exposure. For cosmetic formulations, maintaining purity is critical, with emphasis on strict manufacturing controls to minimize residual impurities such as ethylene oxide, propylene oxide, and 1,4-dioxane.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed Poloxamers, the broader class to which Poloxamine 504 belongs, as safe for use in cosmetics, provided they are formulated to be non-irritating. The panel highlighted that its molecular weight and solubility suggest minimal skin penetration. Manufacturers are urged to adhere to rigorous purification protocols to maintain levels of potential impurities, including ethylene oxide, propylene oxide, and 1,4-dioxane, below established safety thresholds.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamine 504 is a valuable functional ingredient due to its effective surfactant and emulsifying properties, enabling stable cosmetic formulations and efficient cleansing, with a CIR safety assessment of "safe as used" under proper formulation and purification.

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