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Moumoujus

POLOXAMINE 1508.

Insufficient Data CAS 11111-34-5 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Poloxamine 1508 is an X-shaped amphiphilic block copolymer that functions as a non-ionic surfactant and emulsifying agent. It exhibits multi-responsive behavior to temperature and pH, making it a versatile component for formulation stability and potentially supporting skin barrier integrity.

Summary

Surfactant (emulsifying) Drug carrier (delivery system) Membrane integrity support (based on similar compounds) Protein stabilization (based on similar compounds) Chemesthetic sensation modifier

Science

Mechanism of Action

This ingredient operates as an X-shaped amphiphilic block copolymer, comprising poly(ethylene oxide)-poly(propylene oxide) blocks linked to a central ethylenediamine core. Its primary mechanism involves acting as a surfactant and emulsifier, facilitating the creation of stable formulations. Evidence from similar poloxamer-based surfactants indicates a capacity to restore cellular membrane integrity by inserting into damaged lipid bilayers, potentially aiding in the repair of compromised skin barriers. It can also contribute to suppressing protein aggregation and supporting the refolding of denatured proteins. Its structure confers pH and temperature responsiveness, allowing for self-assembly and potential interaction with hydrophobic domains or direct penetration of cellular lipid bilayers.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poloxamines are generally pH-sensitive. Complexes formed with poloxamers in chlorinated organic solvents are unstable when exposed to oxygen, air, or water.

Conflicts

  • Not recommended for fragrance use
  • Not recommended for flavor use
  • Unstable in chlorinated organic solvents with oxygen, air, or water

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Poloxamine 1508. It is not advised for use in fragrance or flavor applications due to unspecified reasons.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Poloxamine 1508 shows promise as a versatile surfactant and potential delivery system with structural benefits for skin, but specific clinical data and safety assessments for cosmetic use are currently insufficient.

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