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Moumoujus

POLOXAMINE 1504.

Insufficient Data CAS 11111-34-5 / SURFACTANT - EMULSIFYING

Poloxamine 1504 is a sophisticated block polymer, designed with distinct hydrophilic and hydrophobic segments built around an ethylenediamine core. This amphiphilic structure allows it to function as a highly effective surfactant and emulsifier, seamlessly blending typically immiscible components in skincare formulations.

Summary

Emulsifying Surfactant Wound Healing Support Anti-inflammatory

Science

Mechanism of Action

As a surface-active agent, Poloxamine 1504 operates by significantly lowering surface tension, a key property for stabilizing emulsions. In biological contexts, poloxamines are known to interact with cell membranes, which can reduce unwanted protein adsorption and cellular adhesion. Research suggests these polymers may also enhance local blood flow and alleviate inflammation in compromised skin and soft tissues. Furthermore, its surface tension-reducing action aids in wound cleansing and debridement by facilitating the removal of bacteria and cellular debris. Poloxamines can also influence the activity of matrix metalloproteinases (MMPs), potentially supporting wound healing by assisting in the degradation of damaged collagen while safeguarding healthy tissue.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While Poloxamine 1504 is recognized in SCCS documents as a cosmetic ingredient and emulsifier, a dedicated and comprehensive safety assessment by bodies such as CIR or SCCS, including specific maximum concentration recommendations for cosmetic use, has not been identified in the available data.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Poloxamine 1504 exhibits intriguing mechanistic properties potentially beneficial for skin health and formulation stability, but the current absence of specific cosmetic clinical efficacy data and comprehensive safety reviews limits its immediate precision skincare utility.

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