Science
Mechanism of Action
This ingredient functions by significantly lowering the interfacial tension at the boundary between oil and water, thereby enabling the formation and stabilization of emulsions in cosmetic products. As a poloxamer, POLOXAMINE 1302 is known to integrate into mammalian cell membranes, which can reduce protein adsorption and cell adhesion. This interaction is also associated with its potential to enhance localized blood flow and mitigate inflammatory responses in compromised skin, in addition to its capacity to act as a carrier for other active compounds.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Poloxamine 1302, but indicated 'insufficient data' for poloxamines generally. A broader CIR review of other poloxamers noted the absence of reproductive and developmental toxicity data. However, based on molecular weight and solubility, low and slow skin penetration is anticipated. The CIR panel emphasized the necessity of stringent purification to maintain levels of impurities such as ethylene oxide, propylene oxide, and 1,4-dioxane below established limits. The SCCS (formerly SCCNFP) has acknowledged Poloxamine 1302 for nomenclature and classified it as an emulsifier. Cosmetic ingredients in the US, excluding color additives, do not typically require pre-market FDA approval.
Your Skin
Skin Compatibility
Our Assessment
Verdict
POLOXAMINE 1302 is a functional emulsifier and surfactant with compelling potential biological properties, yet comprehensive safety data specifically for cosmetic applications remains insufficient for a definitive rating by expert panels.
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References
Sources