Science
Mechanism of Action
As a nonionic surfactant and triblock copolymer, Poloxamine 1104 provides essential emulsifying, solubilizing, and stabilizing properties for cosmetic formulations, owing to its balanced hydrophilic and lipophilic segments. On a cellular level, it precisely targets antigen-presenting cells (APCs) to activate SHP-1, which consequently reduces pro-inflammatory IL-4 and IL-13 signaling. This action specifically prevents the activation of T and B effector cells while simultaneously increasing regulatory T and B cells, effectively rebalancing the immune response to a less inflammatory, more homeostatic state within the skin.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
Poloxamine 1104 primarily functions as a formulation stabilizer and an active pharmaceutical ingredient in development. There is no indication it is commonly 'dusted' or overhyped in skincare beyond its established roles.
The Formula
Formulation
Stability
Exhibits stability across a broad pH spectrum, making it versatile for various formulation types. Optimal storage involves keeping it away from extreme temperatures and direct sunlight to maintain integrity.
Safety
Safety Profile
While Poloxamine 1104 itself lacks specific maximum concentration limits from CIR, SCCS, or FDA, it is generally considered safe for use within recommended cosmetic guidelines. The Cosmetic Ingredient Review Expert Panel has previously assessed related dimethicone and methicone polymers as safe, citing their large molecular weights which limit skin absorption. Clinical research on Poloxamine 1104 for Eosinophilic Esophagitis demonstrated a favorable safety profile with no related serious adverse events.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamine 1104 is a versatile polymer offering robust formulation stabilization and solubilization, alongside compelling preclinical and clinical evidence for its role as an immune modulator in inflammatory conditions, positioning it as a valuable ingredient for advanced skincare formulations.
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References
Sources