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Moumoujus

POLOXAMER 288.

Valuable CAS 9003-11-6 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Poloxamer 288 is a versatile synthetic polymer functioning as a surfactant, emulsifying agent, cleansing agent, and solubilizer. It is key for stabilizing cosmetic formulations, enhancing product texture, and ensuring efficient dispersion and cleansing.

Summary

Surfactant Emulsifying Agent Cleansing Agent Solubilizing Agent Formulation Stabilizer Texture Enhancer Skin Permeation Enhancer

Science

Mechanism of Action

As an amphiphilic block copolymer, Poloxamer 288 primarily operates by reducing surface tension, which is crucial for forming stable emulsions and dissolving oily ingredients within water-based systems. This action also facilitates the mixing of water with oil and dirt, enabling effective cleansing. Beyond these roles, related poloxamers exhibit more complex biological functions such as maintaining cell membrane integrity and displaying anti-inflammatory characteristics, hinting at broader benefits.

Research

Clinical Evidence

High confidence
Effective range 0.005–20%
Optimal

N/A

Key findings

  1. 01 Clinical tests by the Cosmetic Ingredient Review (CIR) Expert Panel consistently showed negative results for dermal irritation and sensitization across various Poloxamers, including Poloxamer 288, when used at concentrations between 0.005% and 20%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poloxamers are utilized for stabilizing formulations and enhancing texture. As amphiphilic block copolymers, they are water-soluble and act as effective solubilizers for oily ingredients in water-based formulas.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
20%
Sensitization risk Low

The CIR Expert Panel concluded that Poloxamers, including Poloxamer 288, are safe for use in cosmetics at concentrations up to 20%. While specific reproductive and developmental toxicity data are absent, the ingredient's molecular weight and solubility suggest minimal and slow skin penetration. The CIR Panel emphasizes strict adherence to purification procedures to keep impurities like ethylene oxide, propylene oxide, and 1,4-dioxane below established limits. Poloxamer 188 is an FDA-approved biocompatible block copolymer, but Poloxamer 288 lacks a specific dedicated FDA review. It is permitted for use under the general provisions of the European Union's Cosmetics Regulation, without a specific SCCS opinion.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamer 288 is a valuable multifunctional ingredient, recognized for its excellent safety profile, broad skin compatibility, and crucial role in enhancing formulation stability and efficacy across various skincare and personal care products.

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