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Moumoujus

POLOXAMER 215.

Valuable CAS 9003-11-6 / SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Poloxamer 215 is a versatile nonionic triblock copolymer, renowned for its amphiphilic structure, which enables it to function effectively as a mild cleansing, emulsifying, and solubilizing agent in skincare formulations.

Summary

mild cleansing agent emulsifying solubilizing surfactant

Science

Mechanism of Action

This ingredient operates as a surfactant by forming a unique triblock structure of hydrophilic polyoxyethylene (PEO) and hydrophobic polyoxypropylene (PPO) blocks. This amphiphilic nature allows it to significantly reduce the surface tension between substances, aiding in the formation of stable emulsions, dissolving oil and dirt for gentle cleansing, and enhancing the solubility of otherwise immiscible ingredients.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Poloxamer 215 serves a core functional role in formulations as a surfactant and emulsifier, making it an active component rather than an ingredient typically 'dusted' for marketing claims.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Aqueous solutions of poloxamers exhibit broad pH stability, remaining robust in the presence of acids, alkalis, and metal ions. However, formulations should account for potential mold growth and the possibility of degradation, which, as seen in related poloxamers like Poloxamer 188, can lead to a pH drop due to the formation of formic and acetic acids. Antioxidants may influence its stability profile.

Conflicts

  • Phenols (observed with Poloxamer 188)
  • Parabens (observed with Poloxamer 188)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
20%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed Poloxamers, including Poloxamer 215, as safe for use in cosmetic products up to 20% concentration. This assessment is supported by clinical tests demonstrating uniformly negative results for dermal irritation and sensitization. Due to its molecular weight and solubility, minimal skin penetration is expected. Regulatory bodies emphasize the necessity of rigorous purification to maintain impurity levels of substances like ethylene oxide, propylene oxide, and 1,4-dioxane below established safety limits. It is also recognized as an FDA-approved pharmaceutical excipient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Poloxamer 215 is a highly valuable, well-tolerated ingredient crucial for its mild cleansing, emulsifying, and solubilizing properties across a wide range of cosmetic and personal care applications.

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