Science
Mechanism of Action
Poloxamer 182 functions as a non-ionic surfactant and emulsifier due to its amphiphilic nature, derived from a block copolymer structure of water-soluble polyethylene oxide and less water-soluble polypropylene oxide. This allows it to reduce the surface tension between immiscible liquids, forming stable emulsions. As a cleansing agent, it facilitates the mixing of water with oily debris and dirt, enabling their effective removal from skin and hair.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Poloxamer 182 is stable under recommended storage conditions. An aqueous solution may exhibit turbidity as the temperature approaches its cloud point, which is observed between 22-26°C for a 10% solution.
Conflicts
- strong acids
- strong bases
- high concentrations of electrolyte solutions
- strong oxidizing agents
- strong reducing agents
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has determined Poloxamer 182, like other Poloxamers, to be safe for use in cosmetics. While it may act as a minimal ocular irritant, it is not identified as a dermal irritant or sensitizer. Although reproductive and developmental toxicity data are not explicitly available, its molecular weight and solubility suggest a low potential for skin penetration. Industry best practices recommend ensuring purification processes keep levels of impurities, such as 1,4-dioxane, ethylene oxide, and propylene oxide, below established regulatory limits.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Poloxamer 182 is a valuable formulation component, providing essential emulsifying and cleansing properties with broad skin compatibility and a low risk of irritation.
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