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Moumoujus

PLACENTAL EXTRACT.

Avoid CAS -

Placental extract, a complex blend of growth factors and biomolecules, has been explored for its potential to hydrate, regenerate, and improve skin elasticity. However, its use in cosmetics faces severe restrictions due to significant safety concerns and regulatory prohibitions.

Summary

Humectant Skin conditioning Antistatic (for hair) Hair conditioning Moisturizing Nourishing Regenerating Film-forming Protecting Restructuring

Science

Mechanism of Action

This ingredient functions by stimulating fibroblasts to enhance collagen and elastin synthesis, thereby improving skin firmness and reducing the appearance of lines. It supports skin hydration by mitigating transepidermal water loss and offers antioxidant protection against environmental stressors. Additionally, it exhibits anti-inflammatory effects, promotes cellular regeneration, aids in wound healing, and may contribute to a more even skin tone through increased cell turnover.

Research

Clinical Evidence

Medium confidence
Effective range 200–200%
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

Placental extract is often 'dusted' in cosmetic formulations due to significant safety and regulatory concerns. The European Union prohibits human-derived placental ingredients due to risks of disease transmission, and the FDA considers it potentially hazardous with reported side effects. The CIR Expert Panel also found insufficient data to support its safety for cosmetic use.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

As sensitive biomolecules, placental extracts demand carefully formulated systems, potentially utilizing gentle humectants, stabilizers, or encapsulation technologies to maintain integrity. Optimal stability is observed within a pH range of 6.1-7.0.

Conflicts

  • strong acids
  • high concentrations of alcohol
  • aggressive exfoliants

Safety

Safety Profile

CIR Status
Insufficient data
Pregnancy
Caution
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel concluded insufficient data for safety, highlighting concerns about potential metabolic/endocrine activity and the risk of pathogenic viruses or infectious agents. The European Union (Regulation (EC) No 1223/2009/Annex II) prohibits human-derived placental ingredients due to disease transmission risks. The FDA also deems placenta extract potentially hazardous, not recognizing it as a cosmetic ingredient, and its use is subject to restrictions and warnings due to reported side effects. Concerns regarding endocrine activity suggest it is not safe for use during pregnancy.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite some reported benefits, placental extract poses significant safety concerns and is subject to strict regulatory prohibitions, rendering it inappropriate for cosmetic use.

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