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Moumoujus

PLACENTAL ENZYMES.

Insufficient Data CAS 85195-59-5 / HAIR CONDITIONING, SKIN CONDITIONING

Placental enzymes are a complex group of biomolecules often found within broader placental extracts, recognized for their potential to stimulate cellular proliferation and tissue regeneration. They are associated with skin renewal, contributing to a brighter, smoother, and more elastic complexion through various biochemical pathways. Moumoujus is committed to formulating with ingredients backed by rigorous safety and efficacy data.

Summary

Skin conditioning Exfoliation Antioxidant Anti-aging Skin brightening

Science

Mechanism of Action

Placental enzymes function as signaling molecules, with specific types like heat-stable alkaline phosphatase, diamine oxidase, and oxytocinases contributing to skin renewal. They facilitate the breakdown of dead skin cells for exfoliation and stimulate the proliferation of both dermal fibroblasts and epidermal keratinocytes, enhancing overall skin turnover. Furthermore, these enzymes are known to boost collagen and elastin production, improve antioxidant enzyme gene expression (e.g., SOD-1, SOD-3, catalase), and reduce tyrosinase activity for potential skin brightening effects.

Research

Clinical Evidence

Medium confidence
Effective range 0.125–1%
Optimal

N/A

Key findings

  1. 01 Porcine placenta ferment filtrate stimulated Normal Human Dermal Fibroblast (NHDF) proliferation in a dose-dependent manner.
  2. 02 Equine placenta ferment filtrate stimulated Normal Human Dermal Fibroblast (NHDF) proliferation in a dose-dependent manner.
  3. 03 Porcine placenta ferment filtrate stimulated Normal Human Epidermal Keratinocyte (NHEK) proliferation in a dose-dependent manner.
  4. 04 Equine placenta ferment filtrate stimulated Normal Human Epidermal Keratinocyte (NHEK) proliferation in a dose-dependent manner.

Transparency

Dusting Analysis

Not commonly dusted

Data to determine common dusting practices or specific dusting thresholds for placental enzymes is not available in the provided research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Placental enzymes are typically obtained via aqueous extraction, indicating water solubility. Their specific composition and biological efficacy are influenced by preparation methods. Certain placental ferment filtrates have demonstrated stability under high-temperature processing, specifically tolerating heat sterilization at 121 °C.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has determined that current data is insufficient to establish the safety of Placental Enzymes in cosmetics. They emphasize that any cosmetic use must be free of detectable metabolic or endocrine activity. Additional safety assessments are required, including skin sensitization, reproductive and developmental toxicity, photosensitization, genotoxicity, and ocular toxicity. Furthermore, any use must guarantee the absence of pathogenic viruses or infectious agents. The European Union prohibits human-derived ingredients in cosmetics due to disease transmission concerns, and the FDA does not recognize certain placental extracts (those with assumed hormonal activity) as cosmetic ingredients, despite reported usage.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite promising in-vitro efficacy, the overall safety profile for placental enzymes is considered to have insufficient data by the CIR, coupled with significant regulatory restrictions and concerns regarding potential biological activity and disease transmission, rendering it highly questionable for cosmetic use.

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