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Moumoujus

PIPER NIGRUM FRUIT EXTRACT.

Valuable CAS 84929-41-9 / PERFUMING

Piper Nigrum Fruit Extract is a versatile botanical ingredient renowned for its comprehensive skin benefits, including potent antioxidant defense, support for a brighter and more even complexion, and promotion of skin regeneration.

Summary

Antioxidant Skin Brightening Anti-aging Anti-inflammatory Antimicrobial Wound Healing Support Microcirculation Enhancer Photoprotective Exfoliant

Science

Mechanism of Action

This extract, rich in polyphenols, flavonoids, and the key alkaloid piperine, delivers powerful antioxidant protection by scavenging free radicals, thereby mitigating oxidative stress and UV-induced damage. Its anti-inflammatory and antimicrobial properties, achieved by disrupting bacterial cell walls and metabolic processes, make it beneficial for acne-prone skin. Piper Nigrum Fruit Extract also acts as a natural exfoliant and stimulates microcirculation, contributing to a radiant complexion. Furthermore, it supports wound healing by encouraging fibroblast and keratinocyte proliferation, enhancing collagen deposition, and facilitating re-epithelialisation. Piperine specifically inhibits tyrosinase activity and suppresses TYR and TRP-1 gene transcription for anti-melanogenic effects, while also inhibiting elastase to combat premature aging.

Research

Clinical Evidence

High confidence
Effective range 10 μg/mL–4%%
Optimal

N/A

Key findings

  1. 01 An emulgel containing 4% Piper nigrum extract exhibited 84% antioxidant activity and 82% tyrosinase inhibition, suggesting significant anti-aging and skin brightening potential.
  2. 02 A cold extract demonstrated 78.81% antioxidant activity.
  3. 03 Piperine derivatives in a 5% oil-in-water emulsion showed SPF values between 2.73 and 3.15, confirming photoprotective effects and skin cell non-toxicity.
  4. 04 Several Piper extracts inhibited melanin synthesis (32.05–60.65%) and melanin release (38.06–45.78%) in stimulated B16F10 cells.
  5. 05 An ethanolic extract promoted fibroblast and keratinocyte proliferation, collagen deposition, and re-epithelialisation in a collagen-based system, indicating wound healing support.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Piperine, a primary active component, has low water solubility; its bioavailability and stability can be enhanced through encapsulation techniques. Extracts formulated in 80% ethanol have shown stability in emulgels.

Synergies

  • Other antioxidants (e.g., Vitamin C, Vitamin E) for enhanced free radical scavenging
  • Skin barrier support ingredients (e.g., Ceramides, Niacinamide) to complement wound healing and anti-inflammatory actions
  • Peptides to further support collagen production and anti-aging effects

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Piper nigrum (black pepper) is recognized as Generally Recognized As Safe (GRAS) by the FDA for food use. Piperine extracts have been well-tolerated in human studies. While EWG Skin Deep rates Piper Nigrum Fruit Extract with low concerns for cancer, allergies, and immunotoxicity, patch testing is advised for individuals with extremely sensitive skin due to potential mild irritancy. A specific CIR conclusion for its use as a cosmetic ingredient is not available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Piper Nigrum Fruit Extract offers a valuable multi-active approach to skincare, providing significant antioxidant, anti-aging, and skin brightening benefits with generally low irritancy, though specific cosmetic safety data is still developing.

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