Science
Mechanism of Action
Pimpinella Brachycarpa Extract functions as a protective agent for the skin, primarily by scavenging reactive oxygen species (ROS) to defend against oxidative damage. It also demonstrates anti-inflammatory capabilities by modulating inflammatory cytokine expression, such as reducing CD45, IL-1β, and TNF-α, and by inhibiting nitric oxide (NO) production. Rich in phenylpropanoids, terpenoids, flavonoids, coumarins, sterols, and organic acids, it additionally serves as a skin conditioning agent.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies indicate that an EtOAc soluble extract protects Bel-7404 cells from hydrogen peroxide-induced damage by scavenging intracellular Reactive Oxygen Species (ROS).
- 02 Animal studies (rat periodontitis model) demonstrated that Pimpinella brachycarpa extract significantly reduced alveolar bone loss and inflammatory responses.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Oral studies in mice showed no acute toxicity at 0.75 g/kg BW and no genotoxicity at 0.03-0.12 g/kg BW, suggesting a safe profile for dietary intake (estimated human oral intake 100-300 mg/day). However, specific safety data for topical cosmetic application, including maximum concentration for dermal use, remains unreviewed by the CIR and unidentified by industry sources like The Good Scents Company.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pimpinella Brachycarpa Extract demonstrates promising in vitro antioxidant and in vivo anti-inflammatory effects; however, more targeted human topical research and safety assessments are needed to fully establish its precise cosmetic utility.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources