Science
Mechanism of Action
This ingredient functions principally as a cosmetic colorant. It bestows a red coloration upon cosmetic products, skin, nails, and hair through the physical processes of light absorption and reflection.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 The Scientific Committee on Consumer Safety (SCCS) concluded in 2012 that Pigment Red 57, when used as a direct dye in non-oxidative semi-permanent hair dye formulations at an on-head concentration up to 0.4%, does not pose a risk to consumer health.
- 02 An SCCNFP opinion indicated that Pigment Red 57, at a 10% concentration in propylene glycol, did not induce skin irritation (grade 0) and was not anticipated to be comedogenic in rabbit models, suggesting favorable skin compatibility in certain applications.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Pigment Red 57 demonstrates stability in water, with 97% recovery over 7 days at room temperature in the absence of light (at 0.5% w/v). It has also been reported as stable in cosmetic formulations for up to 7 months at 25ºC, though comprehensive supporting data was noted as incomplete. Care should be taken in highly alkaline environments, as metal ion substitution may lead to thickening of the formulation.
Conflicts
- Alkaline environments (potential for thickening due to metal ion substitution)
Safety
Safety Profile
The Scientific Committee on Consumer Safety (SCCS) concluded in 2012 that Pigment Red 57 is safe for consumer health when used as a direct dye in non-oxidative hair dye formulations at a maximum on-head concentration of 0.4%. However, the SCCS recommended further assessment for its safety when used as a colorant in other cosmetic products due to potential for additional consumer exposure. Pigment Red 57, also known as D & C Red No. 6, is approved by the FDA for use in pharmaceuticals and cosmetics but is restricted for use in cosmetics around the eyes. Conflicting irritation data exists: an SCCNFP opinion found no skin irritation at 10% in rabbit studies, while another animal study noted mild irritation to rabbit skin and eyes at 10% and slight irritation at 1% in an HET-CAM test.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Pigment Red 57 is an optional ingredient, primarily valued for its vibrant red coloring properties in cosmetic formulations, with generally acceptable safety parameters when utilized within established regulatory guidelines, despite some conflicting irritation data.
Related
Similar Ingredients
Finding similar ingredients…