Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PIDOBENZONE.

Valuable CAS 138506-45-3 / SKIN CONDITIONING

Pidobenzone is an active compound primarily utilized in precision dermatological treatments for hyperpigmentation. Clinical trials indicate its significant efficacy in reducing the appearance of melasma and solar lentigines, making it a targeted solution for specific skin discolorations.

Summary

Hyperpigmentation treatment Skin tone evening Melanin regulation

Science

Mechanism of Action

While its precise mechanism of action is not fully elucidated in the provided data, Pidobenzone is understood to influence melanin production or distribution within the skin, thereby targeting hyperpigmentation disorders such as melasma and solar lentigines.

Research

Clinical Evidence

High confidence
Effective range 4–4%
Optimal

4%

Key findings

  1. 01 A 16-week clinical study demonstrated that Pidobenzone 4% (K5 lipogel), applied twice daily, safely and effectively treated epidermic melasma. This resulted in over 75% improvement in the Melasma Area and Severity Index (MASI) for 100% of participants with epidermic cases, with no reported side effects or relapses.
  2. 02 Further research indicates that Pidobenzone 4% serves as an effective adjuvant therapy for solar lentigines. It improves therapeutic outcomes and prevents post-iatrogenic hyperpigmentation when used alongside fractional CO2 laser or cryotherapy procedures.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Pidobenzone exhibits pH-dependent solubility, suggesting it behaves as a weak acid. Optimal formulation often involves pH adjustments, the inclusion of co-solvents (water-miscible organic solvents), specific excipients, solid dispersions, nanosuspensions, or lipid-based systems to enhance its dissolution. Its observed use in 'lipogel' formulations further suggests it is likely lipophilic or requires specific solubilization in aqueous systems.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
4%
Sensitization risk Unknown

Clinical studies involving Pidobenzone 4% applied for 16 weeks reported it to be safe and effective, with no observed side effects or relapses within the study population. However, comprehensive safety assessments by regulatory bodies such as CIR, SCCS, or FDA for broader cosmetic application are not documented in the provided research.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Pidobenzone demonstrates significant clinical efficacy in targeted hyperpigmentation treatments, particularly for melasma and solar lentigines, though regulatory safety reviews for broader cosmetic application are not yet available.

Related

Similar Ingredients

Finding similar ingredients…