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Moumoujus

PICHIA/RESVERATROL FERMENT EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

This advanced fermented active utilizes Pichia yeast to enhance the skin's absorption and efficacy of resveratrol, a potent polyphenol. It delivers comprehensive anti-aging benefits, significantly improving skin tone, elasticity, and hydration while visibly reducing fine lines and wrinkles. Its robust antioxidant and anti-inflammatory properties also soothe irritation and provide critical protection against environmental aggressors.

Summary

Antioxidant Skin Brightening Anti-aging Anti-inflammatory Hydrating Collagen Booster Wound Healing UV Protection

Science

Mechanism of Action

Pichia/Resveratrol Ferment Extract significantly boosts resveratrol's bioavailability for skin application through Pichia Pastoris yeast fermentation. This process converts resveratrol into more accessible intermediates, augmenting total protein expression. On a cellular level, it exhibits potent antioxidant effects by activating Nrf2/ARE and other critical signaling pathways. It robustly stimulates collagen production, particularly Collagen IV, alongside types I, II, and III, and calms inflamed skin via mechanisms such as COX1 inhibition and preventing NFκB activation. The extract further supports wound healing, modulates tyrosinase activity for skin brightening, promotes fibroblast proliferation, and safeguards cellular DNA from UV-induced damage, contributing to enhanced skin hydration, elasticity, and a revitalized appearance.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 Demonstrates significant improvements in skin tone, lightening, and brightening, alongside strong antioxidant effects. It enhances collagen IV synthesis, improves skin hydration and elasticity, and minimizes the appearance of fine lines and wrinkles, while promoting wound healing and protecting from UV DNA damage.
  2. 02 Showed significantly superior efficacy compared to a 5% Pichia Ferment control in improving skin tone by Day 14 and reducing fine lines by Day 28.
  3. 03 Offers skin brightening benefits comparable to 1.0% Ascorbic Acid, with a statistically significant reduction in melanin production.
  4. 04 Resulted in a statistically significant reduction in COX1 activity, indicating potent anti-inflammatory effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Optimal stability is maintained by avoiding temperatures exceeding 40°C. For best preservation, store in a cool, dark, and dry environment, shielded from direct light and humidity.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has issued an 'Insufficient Data Announcement' for yeast-derived ingredients, including those from Pichia species. They specifically require confirmatory dermal sensitization data, evidence of food use/GRAS (Generally Recognized As Safe) status for the yeast species, or 28-day dermal toxicity data, along with information on Qualified Presumption of Safety (QPS) status from the European Union. While the EWG Skin Deep database rates it as 'Restricted' for EWG VERIFIED products without adequate substantiation, it notes 'LOW' concern for cancer and allergies/immunotoxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

This ingredient demonstrates significant multi-faceted skin benefits, including potent brightening, anti-aging, and anti-inflammatory properties; however, further safety data is required by the CIR Expert Panel to fully confirm its safety profile.

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