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Moumoujus

PICHIA R-SH-POLYPEPTIDE-19 FERMENT EXTRACT FILTRATE.

Insufficient Data / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

This bio-fermented ingredient, derived from Pichia pastoris yeast, delivers a filtrate rich in polypeptides, potentially including recombinant human collagen. It is engineered to support skin regeneration, enhance barrier function, and offer comprehensive benefits across various skin concerns.

Summary

Skin Conditioning Skin Protecting Anti-inflammatory Antioxidant Barrier Repair Oil Control Soothing Anti-aging

Science

Mechanism of Action

Operating at a cellular level, this ingredient stimulates skin cell turnover and supports regeneration, leading to improved skin texture. It reinforces the skin's natural barrier, aiding in hydration maintenance, and offers antioxidant protection against free radical damage. Its polypeptide components are believed to activate endogenous repair pathways, contributing to anti-aging by reducing the appearance of lines and improving elasticity, while also calming irritation.

Research

Clinical Evidence

Low confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 A study involving Pichia pastoris fermentation lysate filtrate demonstrated efficacy in resisting allergy, relieving inflammation, preventing sunburn, regulating skin micro-ecology, and controlling oil by inhibiting lipid droplet synthesis. It also showed promise in repairing skin barriers, enhancing both micro-ecological and immune defenses.
  2. 02 A preferred concentration of 5% in cosmetic formulations has been noted for its beneficial effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a ferment filtrate containing polypeptides, its stability may be influenced by factors such as proteases. However, specific stability data for this exact ingredient in cosmetic formulations is not readily available.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has issued an 'Insufficient Data Announcement' for related Pichia Ferment Extract Filtrate ingredients, including this one. The panel requires confirmatory dermal sensitization data, along with information on food use/GRAS/QPS status for the yeast species, or systemic toxicity data. Currently, no uses for this ingredient have been reported in the FDA's Voluntary Cosmetic Registration Program (VCRP) survey.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While initial research suggests a broad spectrum of potential skin benefits, the current lack of comprehensive safety data from independent reviews necessitates caution and further study before widespread recommendation.

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