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Moumoujus

PHYTONADIONE EPOXIDE.

Questionable CAS 25486-55-9 / ASTRINGENT

Phytonadione Epoxide, an oxidized derivative of Vitamin K1, functions as a skin conditioning agent within the intricate Vitamin K cycle. It is precisely engineered to address visible concerns such as skin redness (erythema) and the appearance of dark under-eye circles by enhancing microcirculation. This ingredient also contributes to overall skin health, improving hydration, elasticity, and texture while offering anti-aging benefits.

Summary

Skin Conditioning Astringent Antioxidant Microcirculation Enhancer Redness Reducer Dark Circle Corrector Anti-aging Agent Skin Regenerator Capillary Strengthening

Science

Mechanism of Action

This ingredient enhances blood microcirculation and prevents blood extravasation, critical actions in reducing skin redness and the appearance of dark under-eye circles. It specifically targets hemosiderin build-ups, maintaining iron in its bivalent (ferrous) form to mitigate violet pigmentation responsible for dark deposits. Furthermore, Phytonadione Epoxide promotes cellular regeneration, functions as an antioxidant to protect against free radicals, and strengthens blood vessel walls to decrease capillary fragility.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–3%
Optimal

0.1%

Key findings

  1. 01 At 0.1% concentration, Phytonadione Epoxide demonstrates significant reduction in skin redness (erythema), with improvements noted across the 0.1-0.5% range.
  2. 02 When delivered via nanovesicles at 3% concentration, this ingredient reduces under-eye circles, erythema, and skin irritations. It concurrently enhances skin hydration, elasticity, and texture, providing comprehensive anti-aging benefits.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding 'dusting' is not available in the provided research data.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Similar to Vitamin K1, Phytonadione Epoxide is inherently sensitive to light and oxygen, and its integrity can be compromised by alkalis. Heat sterilization may lead to increased levels of (E)-epoxide.

Conflicts

  • alkalis
  • strong reducing agents
  • light (photo-instability)
  • oxygen

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The European Commission has initiated an active 'call for data' (deadline May 18, 2026) to thoroughly assess the safety of phytonadione epoxide in cosmetic products. This action follows a documented increase in reported cases of allergic contact dermatitis (ACD), particularly observed with eye contour products in Spain. Previous SCCS opinions also highlighted concerns regarding cutaneous allergy for Vitamin K1 and its oxide due to insufficient safety data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While demonstrating efficacy in reducing skin redness and dark circles, Phytonadione Epoxide carries a notable risk of allergic contact dermatitis and is currently under active safety review, necessitating cautious formulation and use.

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