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Moumoujus

PHYTOLACCA DECANDRA ROOT EXTRACT.

Avoid CAS 84961-56-8 / NOT REPORTED

Phytolacca Decandra Root Extract is an ingredient with a history of traditional topical use for various skin conditions, including rashes and infections. While in-vitro studies show potential for inducing apoptosis in melanoma cells and a related species demonstrates antioxidant activity, significant safety concerns classify it as unsuitable for modern cosmetic applications.

Summary

skin conditioning antioxidant anti-inflammatory antimicrobial

Science

Mechanism of Action

This extract primarily functions by inducing apoptosis in skin melanoma cells through caspase-mediated signaling and reactive oxygen species (ROS) generation, as observed in an in-vitro study. Additionally, extracts from the related species Phytolacca dodecandra exhibit antioxidant activity by scavenging free radicals and inhibiting lipid peroxidation. Traditionally, it is recognized for potential anti-inflammatory, detoxifying, and antimicrobial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

This ingredient is explicitly classified as 'Regulated, Forbidden in Europe' for cosmetic use due to its inherent toxicity. All parts of the Phytolacca plant are considered toxic, posing significant safety concerns for topical application. Therefore, its inclusion in cosmetic formulations is strictly prohibited by European regulations, rendering dusting irrelevant.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Conflicts

  • Do not apply to broken or abraded skin.
  • Not for use by individuals with severe liver or kidney disease.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Phytolacca Decandra Root Extract is classified as 'Regulated, Forbidden in Europe' for cosmetic use, indicating it is not approved in the EU due to its inherent toxicity. All parts of the Phytolacca plant are considered toxic and require careful handling. Topical application is contraindicated on broken or abraded skin, and individuals with severe liver or kidney disease should avoid its use. The FDA has not evaluated statements regarding products containing poke root, emphasizing it is not intended to diagnose, treat, cure, or prevent any disease.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite some traditional uses and intriguing in-vitro findings, Phytolacca Decandra Root Extract is explicitly forbidden for cosmetic use in Europe and considered toxic, rendering it unsafe for skincare formulations.

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