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Moumoujus

PHYTOLACCA DECANDRA EXTRACT.

Insufficient Data CAS 84961-56-8 / SKIN CONDITIONING

Derived from the Pokeweed plant, Phytolacca Decandra Extract is recognized for its traditional uses in homeopathic remedies for various skin conditions. Preliminary in vitro research highlights its antioxidant capabilities and potential for targeted cellular effects, though its comprehensive cosmetic profile requires further investigation.

Summary

Antioxidant Skin conditioning

Science

Mechanism of Action

Phytolacca Decandra Extract acts as a free radical scavenger, contributing to antioxidant defense within the skin. Furthermore, in specific cellular models (melanoma cells), it has demonstrated the ability to induce apoptosis (programmed cell death) by initiating caspase-mediated signaling pathways via an elevation in reactive oxygen species (ROS).

Research

Clinical Evidence

Low confidence
Effective range 0–780%
Optimal

N/A

Key findings

  1. 01 An in vitro study revealed that an ethanolic extract of Phytolacca Decandra significantly reduced the proliferation of A375 melanoma cells. This effect was associated with increased reactive oxygen species (ROS) generation and DNA damage, ultimately leading to apoptosis, without exhibiting significant cytotoxicity to normal peripheral blood mononuclear cells. This indicates potential anticancer properties.

Transparency

Dusting Analysis

Not commonly dusted

Given its specific in vitro findings related to melanoma cells and the absence of a comprehensive safety review for general cosmetic use, this ingredient is not commonly utilized at insignificant 'dusting' levels.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Neither the Cosmetic Ingredient Review (CIR) nor the Scientific Committee on Consumer Safety (SCCS) has specifically evaluated Phytolacca Decandra Extract for cosmetic use. While homeopathic preparations are regulated as drugs by the FDA, a distinct FDA status for its use as a topical cosmetic extract is not available. The plant itself (pokeweed) is known to be toxic if ingested. Additionally, dermal irritation tests on rabbits with Phytolacca dodecandra (a related species) indicated slight skin irritation, and eye irritation tests showed significant irritation. These findings suggest a cautious approach and highlight the need for thorough safety assessments in cosmetic formulations.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While displaying promising in vitro anticancer potential and antioxidant activity, the absence of comprehensive safety reviews for cosmetic application and observed irritation potential for related species necessitates more robust clinical and safety data before widespread inclusion in precision skincare.

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