Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

PHOSPHATE BUFFERED SALINE.

Essential CAS - / SOLVENT

Phosphate Buffered Saline (PBS) is a fundamental ingredient in precision skincare, primarily functioning as an isotonic solvent, carrier, and critical pH buffer. It ensures the stability of formulations and optimizes the delivery and efficacy of active ingredients, rather than providing direct skin benefits itself.

Summary

Solvent Carrier pH Buffer

Science

Mechanism of Action

Within skincare formulations, Phosphate Buffered Saline (PBS) performs several vital roles: it acts as an effective solvent, dissolving and homogenously distributing active ingredients, fragrances, and preservatives. As a carrier, it facilitates even application, spreading, and aids in the absorption of other beneficial components into the skin. Crucially, PBS maintains the product's precise pH range, which is paramount for overall formulation stability and ensuring optimal performance of pH-sensitive active compounds. Its isotonic nature, mimicking the body's own fluid balance, contributes to its excellent cellular compatibility.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 7.4
0 7 14

Stability

As a buffer solution, PBS is typically formulated to maintain a pH around 7.4, although adjustments to pH 7.2 are also common. Consistent pH stability is paramount for the integrity of the formulation and the predictable outcomes of various cosmetic ingredients. Temperature fluctuations during its preparation can influence the dissociation equilibrium, thus preparation at the approximate use temperature is recommended. To prevent microbial proliferation, particularly in its neutral, phosphate-containing environment, sterilization post-preparation is advisable.

Conflicts

  • Divalent metals such as zinc (causes precipitation)

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Phosphate Buffered Saline is safe for cosmetic use, provided it is incorporated into non-irritating formulations. It is generally well-tolerated and considered non-irritating for the majority of individuals, though direct contact with highly concentrated forms or dust may temporarily cause irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

Phosphate Buffered Saline is an essential formulation ingredient, crucial for product stability, ingredient solubility, and efficient delivery of other beneficial compounds, rather than offering direct skin-specific benefits.

Related

Similar Ingredients

Finding similar ingredients…