PHENYLACETALDEHYDE ETHYLENEGLYCOL CYCLIC ACETAL.

The Cosmetic Ingredient Review (CIR) has not conducted an assessment for Phenylacetaldehyde Ethyleneglycol Cyclic Acetal. While a usage level recommendation of up to 6.0000% exists for its concentration within a fragrance blend, no specific maximum concentration for its use in finished cosmetic products is provided. Its parent compound, Phenylacetaldehyde, has been evaluated by the Research Institute for Fragrance Materials (RIFM), which found it not to be genotoxic, with a calculated margin of exposure (MOE) exceeding 100 for repeated dose and developmental/reproductive toxicity. Furthermore, Phenylacetaldehyde exhibits a No Expected Sensitization Induction Level (NESIL) of 590 µg/cm2 for skin sensitization. However, there is no direct SCCS (Scientific Committee on Consumer Safety) opinion for the cyclic acetal itself. References to the FDA disallowing certain related phenylacetaldehyde propyleneglycol acetals are likely pertinent to flavor applications, and a contradictory GRAS (Generally Recognized as Safe) listing for phenylacetaldehyde glyceryl 1,2-cyclic acetal confusingly specifies 'Household Cleaners' as its only use.