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Moumoujus

PHENYL METHYL PYRAZOLONE.

Avoid CAS 89-25-8 / HAIR DYEING

Phenyl Methyl Pyrazolone is an organic compound primarily recognized for its critical role as an oxidative color developer in permanent hair dye systems, where it facilitates the creation of desired hair color.

Summary

Science

Mechanism of Action

This compound functions exclusively within oxidative hair dye formulations by reacting with other dye precursors, such as p-phenylenediamines or p-aminophenols, to generate the desired stable colorants within the hair fiber. There is no documented mechanism of action or beneficial function for Phenyl Methyl Pyrazolone when applied to human skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 No clinical studies demonstrating efficacy or beneficial function of Phenyl Methyl Pyrazolone for direct application on skin have been identified. Available data primarily pertains to its safety and functional role as a color developer in hair dye formulations.

Transparency

Dusting Analysis

Not commonly dusted

Phenyl Methyl Pyrazolone is an ingredient exclusively identified for its utility in hair dye formulations, not skincare. Therefore, considering its application in precision skincare as 'dusting' would be a misapplication of an ingredient intended for a distinct cosmetic category without demonstrated skin benefits.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Phenyl Methyl Pyrazolone exhibits sparing solubility in water (0.74 g/L at 24°C, pH 7.2) and is soluble or slightly soluble in various organic solvents including ethanol, chloroform, and benzene. Solutions containing 0.5% methyl cellulose demonstrated stability for up to 9 days at 4°C and 6 hours at room temperature when stored under inert gas and protected from light. Optimal storage conditions require a cool, well-ventilated place, shielded from UV-radiation/sunlight and humidity. No specific optimal pH range for stability in typical cosmetic formulations has been reported.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.25%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded Phenyl Methyl Pyrazolone is safe for use as a hair dye ingredient. The Scientific Committee on Consumer Products (SCCS) concurs, deeming it safe in oxidative hair dyes at a maximum concentration of 0.5% in the formulation (yielding 0.25% upon application after mixing). While acute oral toxicity studies in rats showed no deaths at 2000 mg/kg, and it was nonmutagenic and noncarcinogenic, the pure substance is classified as causing skin and serious eye irritation. Patch tests indicated slight skin irritation under occlusive conditions, though a 1% concentration showed no irritation and it did not produce a sensitization reaction. Cutaneous absorption is reported to be very low, at 0.08%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

As an ingredient exclusively utilized in hair dye formulations with no demonstrated skincare benefits and noted potential for skin irritation, Phenyl Methyl Pyrazolone is not suitable for precision skincare applications.

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