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PHENOXYACETIC ACID.

Insufficient Data CAS 122-59-8 / PERFUMING

Phenoxyacetic acid is a monocarboxylic acid, structurally resembling glycolic acid, an Alpha Hydroxy Acid. While its derivatives possess recognized pharmacological properties, direct research detailing its efficacy as an active skincare ingredient is presently limited. It is also identified as a metabolite of 2-phenoxyethanol.

Science

Although phenoxyacetic acid shares a structural kinship with glycolic acid, a known exfoliating AHA, a precise mechanism of action for phenoxyacetic acid itself as an active ingredient in skincare formulations has not been explicitly defined in available research. Related compounds have demonstrated antibacterial, antifungal, and anti-inflammatory activities across various applications.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Phenoxyacetic acid exhibits a pKa ranging from 3.17 to 3.7 at 25°C, indicating optimal stability in acidic to slightly acidic environments. It is generally stable but is incompatible with strong bases and strong oxidizing agents, reacting exothermically with all bases.

Conflicts

  • strong bases
  • strong oxidizing agents

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated Phenoxyacetic Acid for cosmetic use, nor has the Scientific Committee on Consumer Safety (SCCS) issued an opinion directly on this ingredient in cosmetics. While it is categorized as 'generally recognized as safe' (GRAS) by the U.S. FDA for minor uses as a food additive and perfume component, this designation does not apply to its role as an active ingredient in skincare.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

Due to an absence of explicit mechanistic data for its active skincare use, coupled with a lack of dedicated safety reviews for cosmetic applications, there is insufficient data to evaluate Phenoxyacetic Acid's role in precision skincare.


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