Science
Mechanism of Action
The primary historical pharmacological action of Phenacetin involved inhibiting prostaglandin G/H synthase 1. However, no specific mechanism of action on skin that would confer cosmetic benefits has been scientifically identified.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data is available regarding specific 'dusting' practices for Phenacetin in cosmetic formulations.
The Formula
Formulation
Stability
A saturated solution of Phenacetin is reported to be neutral (pH ~7). It was historically employed as a stabilizer for hydrogen peroxide.
Safety
Safety Profile
Phenacetin was withdrawn from drug markets in many countries, including the United States (1983) and Canada (1978), due to severe hazardous side effects such as carcinogenicity and kidney-damaging properties. The International Agency for Research on Cancer (IARC) has classified phenacetin as a human carcinogen (Group 2A). It is listed as 'Unacceptable' for EWG VERIFIED products. No specific safety assessment by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) regarding Phenacetin in cosmetic products has been found.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its classification as a human carcinogen and documented severe health risks leading to its withdrawal from drug markets, Phenacetin is an ingredient that should be avoided in all cosmetic formulations.
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References
Sources