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Moumoujus

PETROSELINUM CRISPUM LEAF OIL.

Valuable CAS 84012-33-9 / FRAGRANCE, PERFUMING

Petroselinum Crispum Leaf Oil, derived from parsley leaves, is a botanical extract recognized for its broad spectrum of beneficial properties in skincare. It delivers potent antioxidant, anti-inflammatory, and antimicrobial actions, contributing to skin health and resilience.

Summary

perfuming masking antioxidant anti-inflammatory antimicrobial skin barrier support

Science

Mechanism of Action

This essential oil primarily functions by neutralizing free radicals and mitigating oxidative stress, largely attributed to active constituents like apiol and myristicin. It exerts anti-inflammatory effects by modulating immune responses, specifically suppressing pro-inflammatory cytokines such as IL-33, IL-6, and IL-8, and inhibiting signaling pathways like JAK1/STAT1 and NF-κB, which are critical in inflammatory conditions. Furthermore, it demonstrates in vitro antimicrobial and antifungal capabilities. Parsley extracts can also activate the Nrf2 pathway, bolstering the skin's intrinsic antioxidant defenses, and promote the expression of key barrier proteins like filaggrin and claudin-1, enhancing skin barrier integrity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated strong antioxidant activity (81% inhibition in DPPH test) in vitro at a concentration of 0.52 ± 0.0007 mg/mL.
  2. 02 Exhibited in vitro antimicrobial (bactericidal) and antifungal (fungicidal) activities against various bacterial and fungal strains, with Minimum Inhibitory Concentrations (MIC) of 0.25-1.25% v/v and Minimum Bactericidal/Fungicidal Concentrations (MBC/MFC) of 0.5-2.5% v/v.
  3. 03 Application of a parsley extract ointment (concentration not specified for leaf oil) led to a significant decrease in dermatological parameters (redness, thickness, scaling) in human subjects with dermatitis.

Transparency

Dusting Analysis

Not commonly dusted

Petroselinum Crispum Leaf Oil demonstrates multiple well-researched biological activities that support its use in skincare.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Curled parsley leaf oil is soluble in alcohol and fixed oils and demonstrates stability to alkali. Like most essential oils, it is generally sensitive to light, heat, and air, requiring appropriate storage conditions to maintain its stability and efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Moderate

Although designated as Generally Recognized As Safe (GRAS) by the FDA for use as an essential oil in food, Petroselinum Crispum essential oil (or seed oil CO2 extract) is classified as an 'Irritant' (Xi) and flammable. It is generally considered safe for cosmetic use, but potential for irritation exists, especially for very sensitive skin, and a skin test prior to full application is recommended. The recommended usage level for Petroselinum crispum seed oil CO2 extract in fragrance concentrate is up to 5.0%. Acute oral toxicity tests for an aqueous leaf extract in rats indicated a very low systemic toxicity with an estimated LD50 greater than 5000 mg/kg.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Petroselinum Crispum Leaf Oil is a valuable ingredient, offering significant antioxidant, anti-inflammatory, and antimicrobial benefits for skin health, though sensitive skin types should proceed with caution due to potential irritation.

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References

Sources