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Moumoujus

PETASITES HYBRIDUS ROOT EXTRACT.

Questionable CAS 90082-63-6 / SKIN CONDITIONING

Petasites Hybridus Root Extract, derived from the Butterbur plant, is a botanical ingredient recognized for its potent anti-inflammatory and anti-allergic properties. Its mechanism of action supports skin conditioning, particularly beneficial for sensitive skin types prone to inflammatory responses.

Summary

skin conditioning anti-inflammatory anti-allergic

Science

Mechanism of Action

This extract's efficacy stems from sesquiterpene esters like petasin and isopetasin. It functions by decreasing the production of inflammatory mediators such as prostaglandin E2, leukotriene B4, and cysteinyl-leukotrienes. Petasin specifically inhibits intracellular calcium influx into neutrophils and eosinophils, thereby blocking leukotriene biosynthesis, and exhibits anti-allergic activity by inhibiting COX-2 and PGE2 release.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The primary active compound, petasin, is prone to isomerization into its less active form, isopetasin, when exposed to diluted mineral acids, neutral aluminum oxide, or weakly alkaline reagents. Formulators should consider these incompatibilities to maintain ingredient stability and efficacy.

Conflicts

  • diluted mineral acids
  • neutral aluminum oxide
  • weakly alkaline reagents

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Unknown

A critical safety consideration for Petasites Hybridus Root Extract is the potential presence of hepatotoxic pyrrolizidine alkaloids (PAs) in crude extracts. It is paramount that commercial extracts utilized in skincare are meticulously processed to ensure they are completely free of detectable PAs. The American Academy of Neurology withdrew its endorsement for oral butterbur due to liver toxicity concerns linked to PA content. Use is not recommended during pregnancy or breastfeeding.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While displaying a robust anti-inflammatory mechanism, the critical necessity for PA-free sourcing and the current lack of specific topical clinical efficacy data render its cosmetic application questionable without rigorous supplier verification and further study.

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