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PERFLUOROPROPYLENE.

Avoid CAS 116-15-4 / NOT REPORTED

This profile synthesizes data for Perfluoropolymethylisopropyl Ether, a synthetic fluorinated polymer often associated with or derived from perfluoropropylene. It functions as an emollient, forming a protective, hydrophobic film on the skin to prevent moisture loss and enhance the texture and feel of cosmetic formulations.

Summary

Emollient Film Former Skin Conditioning Moisture Barrier Texture Enhancer

Science

Mechanism of Action

Perfluoropolymethylisopropyl Ether functions as an emollient, promoting a smooth and supple skin feel by creating a thin, highly resistant hydrophobic barrier. This barrier effectively prevents transepidermal moisture loss, helps maintain the skin's natural hydration balance, and contributes to a non-greasy, comfortable texture in cosmetic products. Its low surface tension also facilitates superior spreading and uniform conditioning on skin and hair.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Observed to form a protective film, potentially preventing toxic contact dermatitis in experimental clinical settings.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Perfluoropolymethylisopropyl Ether exhibits excellent chemical stability under normal conditions and does not typically interact with other cosmetic ingredients, thereby enhancing product durability and longevity.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel found insufficient data to determine the safety of Perfluoropolymethylisopropyl Ether and related fluorinated polyethers in cosmetics. This compound is classified as a Per- and Polyfluoroalkyl Substance (PFAS), colloquially known as 'forever chemicals' due to their extreme environmental persistence. PFAS are associated with a range of potential health concerns, including immunotoxicity, thyroid disruption, and adverse reproductive/developmental effects. The FDA actively monitors PFAS in cosmetics and requires additional toxicological research, although a definitive safety conclusion has not yet been drawn. The use of this specific PFAS in cosmetics is widely considered concerning, with organizations like the EWG rating 'Polyperfluoromethylisopropyl Ether' as 'Unacceptable' due to enhanced skin absorption, bioaccumulation potential, and possible non-reproductive organ system toxicity.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Perfluoropropylene, specifically in its Perfluoropolymethylisopropyl Ether form, offers emollient and film-forming properties but is a Per- and Polyfluoroalkyl Substance (PFAS) with insufficient safety data and significant environmental and potential health concerns, warranting its avoidance in precision skincare formulations.

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