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Moumoujus

PERFLUOROISOHEXANE.

Avoid CAS 355-04-4 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Perfluoroisohexane is a fluorocarbon ingredient that acts as a skin conditioning agent and emollient, promoting skin softness and smoothness. Its unique chemical structure allows it to dissolve gases, notably oxygen, at higher concentrations than typical organic solvents.

Summary

Skin Conditioning Emollient

Science

Mechanism of Action

This fluorocarbon functions by creating a conditioning film on the skin's surface, thereby enhancing its softness and smoothness. A distinctive characteristic is its ability to dissolve gases, particularly oxygen, at significantly higher concentrations than conventional organic solvents, a property attributed to its weak intermolecular forces that facilitate gas molecule partitioning.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Perfluoroisohexane exhibits excellent chemical and thermal stability, attributed to its strong carbon-fluorine bonds. While generally immiscible with water and conventional oils, it has been observed to dissolve in silicone oil.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has identified insufficient data, raising questions regarding the practice of grouping fluoropolymers for safety assessments. Perfluoroisohexane belongs to the class of per- and polyfluoroalkyl substances (PFAS), which are a recognized chemical class of concern due to potential human health impacts. California's Health and Safety Code has explicitly banned or deemed PFAS unsafe for cosmetic use. In Europe, the European Chemicals Agency (ECHA) proposed restrictions on PFAS in 2023, with implementation expected in 2026/2027. Based on GHS classifications, 50% of reports indicate it 'Causes skin irritation' (H315), 'Causes serious eye irritation' (H319), and 'May cause respiratory irritation' (H335). Mammalian toxicity data for this specific substance is limited. Environmentally, it is classified as persistent (P) or very persistent (vP) and potentially bioaccumulative (B) or very bioaccumulative (vB).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a PFAS, existing and proposed regulatory bans, limited safety data, and potential for irritation, Perfluoroisohexane is strongly discouraged for use in precision skincare formulations.

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